Target: VPS35.
Conjugate: RPE.
Product Type: Monoclonal.
Clone Number: 7E4.
Immunogen: Full length recombinant human VSP35.
Swiss-Prot: Q96QK1.
Purification: Protein G Purified.
Storage Buffer: PBS pH 7.4, 50% glycerol, 0.09% Sodium Azide.
Concentration: 1 mg/ml.
Specificity: Detects ~92 kDa.
Cellular Localization: Endosome, Lysosome, Vesicles, Cytoplasm, Membrane.
Tissue Specificity: Ubiquitous. Highly expressed in brain, colon, heart, kidney, ovary, placenta, skeletal muscle, small intestine, testis, thymus.
Scientific Background: Vacuolar Protein Sorter-35 (VPS35) is a component of the retromer complex, which is essential for endosome-to-Golgi retrieval of membrane proteins. VPS35 mutations such as D620N have been linked to Parkinson’s Disease (PD) (1,2) and affect retromer function, protein homeostasis, and mitochondria (3).
References: 1. Vilarino-Guell, C. et al. (2011) Am J Hum Genet 89:162–1672. Zimprich, A. et al. (2011) Am J Hum Genet 89:168–1753. Rahman, A.A., Morrison, B.E. (2019) Neurosci 401:1-10.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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