Target Synonym: ARGI;ARG;ARG1;arginase-1;A I;Al;ARG 1;ARGI1;Arginase;Arginase 1;Arginase I;Arginase liver;Arginase type I;Arginase1;liver;Liver Arginase;Liver type arginase;Liver-type arginase;Type I arginase;A I;Al;ARG 1;arg1;ARGI1;Arginase 1;Arginase liver;Arginase type I;Arginase;liver;Arginase-1;Arginase1;Liver type arginase;Liver-type arginase;Type I arginase;Arginase
Background: Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion.
Immunogen: Recombinant Human ARG1/Arginase 1 protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: WB 1:500-1:1000;IHC-P 1:500-1:2500;ICC/IF 1:20-1:100;FCM 1:100-1:500
Calculated MW: 35 kDa
Observed MW: 40 kDa
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