Target Synonym: Pvrl;NECTIN;Mph;Pvr;Pvrl2;Pvs;Nectin2;PRR2;Nectin-2;AI325026 Protein;AI987993 Protein;CD112;Cd112 Protein;Herpes virus entry mediator B;Herpesvirus entry mediator B;HveB;MPH Protein;NECT2;Nectin cell adhesion molecule 2;Nectin-2;nectin-2 Protein;Poliovirus receptor-related protein 2;Pvr Protein;Pvs Protein
Background: Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.
Immunogen: Recombinant Mouse PVRL2 protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: WB 1:500-1:1000;IP 0.2-1 μL/mg of lysate
Calculated MW: 58 kDa
Observed MW: 58 kDa
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