Target Synonym: Bsg;Neurothelin;basigin;EMMPRIN;5A11 antigen;5F7;AI115436;AI325119;BASI;Basic immunoglobulin superfamily;Basigin;Basigin (Ok blood group);Blood brain barrier HT7 antigen;CD 147;CD147;CD147 antigen;Collagenase stimulatory factor;EMMPRIN;Extracellular matrix metalloproteinase inducer;HT-7;HT7 antigen;Leukocyte activation antigen M6;M 6;M6 leukocyte activation antigen;Membrane glycoprotein gp42;OK blood group;OK blood group antigen;TCSF;Tumor cell derived collagenase stimulatory factor;Tumor cell-derived collagenase stimulatory factor
Background: CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. It is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. Recently, CD147 displays increased expression in many cancers, and it has been previously demonstrated to participate in cancer metastasis and progression. Thus, CD147 and its antibody are used as an effective treatment for malignant cancers.
Immunogen: Recombinant Mouse CD147 protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: ICC/IF 1:20-1:100
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