Target Synonym: ADGRE;TM7LN;ADGRE5;CD97;TM7LN1;EMR1;adhesion G protein-coupled receptor E5;BL-Ac[F2];CD_antigen: CD97;CD97 antigen;Leukocyte antigen CD97
Background: This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19.
Immunogen: Recombinant Human CD97 protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: ICC/IF 1:20-1:100;FCM 1:25-1:100
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