Target Synonym: EGP;Megp;Tacstd;EGP314;Ep-CAM;Megp314;Tacstd1;Epcam;MK-1;KSA;EGP40;17 1A;323/A3;35-KD glycoprotein;Adenocarcinoma associated antigen;Adenocarcinoma-associated antigen;Antigen identified by monoclonal AUA1;AUA1;CD326;CD326 antigen;Cell surface glycoprotein Trop 1;Cell surface glycoprotein Trop 2;Cell surface glycoprotein Trop-1;chromosome 4;CO 17A;CO17 1A;CO17A;DIAR5;EGP 2;EGP2;EGP-2;EGP40;Ep CAM;EpCAM1;epithelial cell adhesion molecule;Epithelial Cell Adhesion Molecule Intracellular Domain (EpCAM-ICD);Epithelial cell surface antigen;Epithelial cellular adhesion molecule;Epithelial glycoprotein;Epithelial glycoprotein 1;Epithelial glycoprotein 314;ESA;GA733 1;GA733 2;GA733-2;gastrointestinal tumor-associated antigen 2;gp4;gp40;hEGP 2;hEGP314;HNPCC8;Human epithelial glycoprotein 2;KS 1/4 antigen;KS1/4;KSA;Ly74;Lymphocyte antigen 74;M1S 1;M1S2;M4S1;Major gastrointestinal tumor associated protein GA733 2;Major gastrointestinal tumor-associated protein GA733-2;Membrane component;Membrane component chromosome 4 surface marker (35kD glycoprotein);MIC18;MK 1;MK-1;Neurotrophic tyrosine kinase receptor-related 1;Protein 289A;receptor tyrosine kinase-like orphan receptor 1;ROR1;surface marker;surface marker 1;TACD1;Tacsd1;TROP1;Tumor associated calcium signal transducer 1;Tumor associated calcium signal transducer 2 precursor;Tumor-associated calcium signal transducer 1;tyrosine-protein kinase transmembrane receptor ROR1
Background: Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type I transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.
Immunogen: Recombinant Mouse EpCAM/TROP-1/TACSTD1 protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: IHC-P 1:500-1:2000
English
Deutsch
