Shelf life (days): 365.0
Formulation: 100 µl of protein A-affinity purified monoclonal antibody
Immunogen: Peptide from the C-terminal region of human aminopeptidase N
Clone Designation: RM403
Target specificity: Human
Cross Reactivity: + Aminopeptidase N
Formula Weight: 0.0
Notes: Aminopeptidase N, also known as cluster of differentiation 13 (CD13), is a zinc-dependent and membrane-bound ectopeptidase and type II membrane glycoprotein encoded by ANPEP in humans.{58316,58315} It is composed of a short N-terminal cytosolic domain, a membrane-spanning domain, and five extracellular domains, including a C-terminal catalytic domain.{58315,58317} It is ubiquitously expressed on cell membranes where it functions as a dimer to degrade peptides and proteins containing N-terminal neutral amino acids.{58315} Plasma levels of soluble aminopeptidase N are increased and positively correlated with tumor progression in patients with non-small cell lung cancer (NSCLC).{58316} ANPEP is overexpressed in psoriatic skin lesions, synovial fibroblasts isolated from patients with rheumatoid arthritis, and lymphocytes and peripheral blood mononuclear cells (PBMCs) isolated from patients with multiple sclerosis during acute exacerbation and chronic progression.{58315} Cayman’s Aminopeptidase N/CD13 (C-Term) Rabbit Monoclonal Antibody (RM403) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
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