Shelf life (days): 365.0
Formulation: 100 µg of protein A-affinity purified monoclonal antibody
Immunogen: Peptide corresponding to H2AS1Ph
Clone Designation: RM216
Target specificity: Vertebrates
Cross Reactivity: + H2AS1Ph; + H4S1Ph; - Unmodified H2AS1; - Unmodified H4S1
Formula Weight: 0.0
Notes: Histone H2A is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} Histones are globular proteins with unstructured N-terminal tails and are subject to a variety of post-translational modifications, such as methylation, acetylation, phosphorylation, and citrullination, that can influence chromatin structure and regulate gene transcription.{57056,18136} Phosphorylation of histone H2A at serine 1 (H2AS1Ph) is mediated by p90 ribosomal S6 kinase 5 (RSK5) and is associated with transcriptional repression.{59498} H2AS1Ph is enriched during mitosis in C. elegans, Drosophila, and HeLa cells, as well as during meiotic recombination in mouse spermatozoa.{54369,59481,59491} Cayman's Histone H2AS1Ph Monoclonal Antibody (RM216) can be used for ELISA, immunocytochemistry (ICC), multiplex-based assay, and Western blot (WB) applications. This antibody is cross-reactive with histone H4 phosphorylated at serine 1 (H4S1Ph).
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