Product Description: 3-Methylglutaric acid-d4 is the deuterium labeled 3-Methylglutaric acid[1]. 3-Methylglutaric acid, a leucine metabolite, is a conspicuous C6 dicarboxylic organic acid classically associated with two distinct leucine pathway enzyme deficiencies, 3-hydroxy-3-methylglutaryl CoA lyase (HMGCL) and 3-methylglutaconyl CoA hydratase (AUH)[2][3].
Applications: Metabolism-protein/nucleotide metabolism
Formula: C6H6D4O4
References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Barich DH, et al. 3-Methylglutaric acid as a 13C solid-state NMR standard. Solid State Nucl Magn Reson. 2006 Oct;30(3-4):125-9./[3]Dylan E Jones, et al. 3-Methylglutaric acid in energy metabolism. Clin Chim Acta. 2020 Mar;502:233-239.
CAS Number: 1219798-68-1
Molecular Weight: 150.17
Research Area: Metabolic Disease
Solubility: 10 mM in DMSO
Target: Endogenous Metabolite
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