4-Hydroperoxy Cyclophosphamide-d4, CAS 1246816-71-6

Product Description: 4-Hydroperoxy Cyclophosphamide-d4 is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the proagent Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders[1][2].

Applications: COVID-19-anti-virus

Formula: C7H11D4Cl2N2O4P

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216./[2]4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG

CAS Number: 1246816-71-6

Molecular Weight: 297.11

Compound Purity: 95.0

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO/DMSO : 50mg/mL (ultrasonic)

Target: Apoptosis;DNA Alkylator/Crosslinker;Drug Metabolite;Reactive Oxygen Species

• SKU: MEXHY-117433S-100UG
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-117433S-100UG
• Package Unit: 100 μg
• Quantity Unit: STK