Product Description: 5-Aminosalicylic acid-13C6 hydrochloride (Mesalamine-13C6 hydrochloride; 5-ASA-13C6 hydrochloride) is the 13C labeled 5-Aminosalicylic Acidhydrochloride. 5-Aminosalicylic acid-13C6 hydrochloride acts as a PPARγ agonist, and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1][2][3].
Applications: Metabolism-protein/nucleotide metabolism
Formula: C 13C6H8ClNO3
References: [1]Dammann K, et al. PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. Biochim Biophys Acta. 2015;1853(10 Pt A):2349-2360./[2]Rousseaux C, et al. The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARγ. Carcinogenesis. 2013;34(11):2580-2586./[3]Fang HM, et al. 5-aminosalicylic acid in combination with nimesulide inhibits proliferation of colon carcinoma cells in vitro. World J Gastroenterol. 2007;13(20):2872-2877.
CAS Number: 1261398-47-3
Molecular Weight: 195.55
Research Area: Metabolic Disease
Solubility: 10 mM in DMSO
Target: NF-κB;PAK;PPAR
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