ABT-737-d8, CAS 1217686-68-4

ABT-737-d8, CAS 1217686-68-4
SKU
MEXHY-50907S-100UG
Packaging Unit
100 μg
Manufacturer
MedChemExpress

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Product Description: ABT 737-d8 is the deuterium labeled ABT-737. ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research[1][2][3].

Formula: C42H37D8ClN6O5S2

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. /[2]Ahamed Saleem, et al. Effect of dual inhibition of apoptosis and autophagy in prostate cancer. Prostate. 2012 Sep 1;72(12):1374-81./[3]Clerc P, et al. Polster BM.Rapid Detection of an ABT-737-Sensitive Primed for Death State in Cells Using Microplate-Based Respirometry.PLoS One. 2012;7(8):e42487. Epub 2012 Aug 3./[4]Konopleva M, et al. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell. 2006 Nov;10(5):375-88.

CAS Number: 1217686-68-4

Molecular Weight: 821.48

Compound Purity: 99.11

Research Area: Cancer

Solubility: 10 mM in DMSO/DMSO : 50mg/mL (ultrasonic)

Target: Biochemical Assay Reagents
More Information
SKU MEXHY-50907S-100UG
Manufacturer MedChemExpress
Manufacturer SKU HY-50907S-100UG
Package Unit 100 μg
Quantity Unit STK
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