Aficamten-d3

Product Description: Aficamten-d3 (CK-274-d3) is deuterium labeled Aficamten. Aficamten (CK-274) is a potent cardiac myosin inhibitor with an IC50 of 1.4 μM. Aficamten can be used for the research of hypertrophic cardiomyopathy (HCM)[1].

Applications: Neuroscience-Neuromodulation

Formula: C18H16D3N5O2

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216./[2]Chihyuan Chuang, et al. Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy. J Med Chem. 2021 Oct 14;64(19):14142-14152.

Molecular Weight: 340.39

Research Area: Cardiovascular Disease

Target: Isotope-Labeled Compounds;Myosin

• SKU: MEXHY-W759845-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-W759845-0
• Package Unit: Get quote
• Quantity Unit: STK