Apremilast-d5, CAS 1258597-47-5

Product Description: Apremilast-d5 is a deuterium labeled Apremilast. Apremilast is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM[1].

Applications: COVID-19-immunoregulation

Formula: C22H19D5N2O7S

References: [1]Perez-Aso M, et al. Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors. Arthritis Res Ther. 2015 Sep 15;17:249.

CAS Number: 1258597-47-5

Molecular Weight: 465.53

Compound Purity: 98.63

Research Area: Inflammation/Immunology

Solubility: DMSO : 44mg/mL (ultrasonic)

Target: Apoptosis;Phosphodiesterase (PDE);TNF Receptor

• SKU: MEXHY-12085S-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-12085S-10
• Package Unit: 10 mg
• Quantity Unit: STK