Aprepitant-13C2,d2 (Major), CAS 1217676-37-3

Aprepitant-13C2,d2 (Major), CAS 1217676-37-3
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MEXHY-W777166-0
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MedChemExpress

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Product Description: Aprepitant-13C2,d2 (Major) (MK-0869-13C2,d2) is 13C labeled Aprepitant. Aprepitant (MK-0869) is a selective and high-affinity neurokinin 1 receptor antagonist with a Kd of 86 pM.

Applications: Metabolism-protein/nucleotide metabolism

Formula: C21 13C2H19D2F7N4O3

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216./[2]Martinez AN, et al. Aprepitant limits in vivo neuroinflammatory responses in a rhesus model of Lyme neuroborreliosis. J Neuroinflammation. 2017 Feb 15;14(1):37./[3]Bayati S, et al. Inhibition of tachykinin NK1 receptor using aprepitant induces apoptotic cell death and G1 arrest through Akt/p53 axis in pre-B acute lymphoblastic leukemia cells. Eur J Pharmacol. 2016 Nov 15;791:274-283./[4]Mannangatti P, et al. Differential effects of aprepitant, a clinically used neurokinin-1 receptor antagonist on the expression of conditioned psychostimulant versus opioid reward. Psychopharmacology (Berl). 2017 Feb;234(4):695-705./[5]Barrett JS, et al. Pharmacologic rationale for the NK1R antagonist, aprepitant as adjunctive therapy in HIV. J Transl Med. 2016 May 26;14(1):148.

CAS Number: 1217676-37-3

Molecular Weight: 538.42

Research Area: Neurological Disease;Endocrinology;Cancer

Target: Antibiotic;Bacterial;HIV;Isotope-Labeled Compounds;Neurokinin Receptor
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SKU MEXHY-W777166-0
Manufacturer MedChemExpress
Manufacturer SKU HY-W777166-0
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