Product Description: ATP-18O4 (disodium salt) is the 18O labeled ATP disodium salt[1]. ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt is an important endogenous signaling molecule in immunity and inflammation[2][3].
Applications: Metabolism-protein/nucleotide metabolism
Formula: C10H16N5NaO9 18O4P3
References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Bonora M, et al. ATP synthesis and storage. Purinergic Signal. 2012 Sep;8(3):343-57./[3]M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov112(2):358-404./[4]Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov107:104514./[5]Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013 8(5): e63759.
CAS Number: 2483830-61-9
Molecular Weight: 538.17
Research Area: Metabolic Disease
Solubility: 10 mM in DMSO
Target: Endogenous Metabolite
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