Canagliflozin-d6

Product Description: Canagliflozin-d6 is the deuterium labeled Canagliflozin[1]. Canagliflozin (JNJ 28431754) is a selective SGLT2 inhibitor with IC50s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively[2].

Applications: Neuroscience-Neuromodulation

Formula: C24H19D6FO5S

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Liang Y, et al. 
Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models.
 PLoS One. 2012;7(2):e30555.

Molecular Weight: 450.55

Research Area: Metabolic Disease

Solubility: 10 mM in DMSO

Target: SGLT

• SKU: MEXHY-10451S2-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-10451S2-1
• Package Unit: 1 mg
• Quantity Unit: STK