Clobetasol propionate-d5, CAS 2280940-18-1

Product Description: Clobetasol propionate-d5 is a deuterium substitute of Clobetasol propionate. Clobetasol propionate is a potent, selective CYP3A5 inhibitor with a IC50 of 0.206 μM and has potential for use in the study of psoriasis and other skin diseases[1][2].

Applications: COVID-19-immunoregulation

Formula: C25H27D5ClFO5

References: [1]Wright WC, et al. Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5. J Med Chem. 2020 Feb 13;63(3):1415-1433./[2]Zeigler M, et al. Anti-CD11a ameliorates disease in the human psoriatic skin-SCID mouse transplant model: comparison of antibody to CD11a with Cyclosporin A and clobetasol propionate. Lab Invest. 2001 Sep;81(9):1253-61.

CAS Number: 2280940-18-1

Molecular Weight: 472.00

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: Cytochrome P450;Isotope-Labeled Compounds

• SKU: MEXHY-13600S1-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-13600S1-1
• Package Unit: 1 mg
• Quantity Unit: STK