Crizotinib-d9, CAS 1523580-59-7

Product Description: Crizotinib-d9 (PF-02341066-d9) is deuterium labeled Crizotinib. Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition[1][2][3].

Applications: Cancer-programmed cell death

Formula: C21H13D9Cl2FN5O

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

CAS Number: 1523580-59-7

Molecular Weight: 459.39

Research Area: Cancer

Target: Isotope-Labeled Compounds

• SKU: MEXHY-50878S2-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-50878S2-0
• Package Unit: Get quote
• Quantity Unit: STK