Product Description: Domperidone-13C6 (R33812-13C6) is 13C labeled Domperidone. Domperidone (R33812) is an orally active and selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine[1].
Applications: Neuroscience-Neuromodulation
Formula: C18 13C6H32ClN5O2
References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216./[2]Reddymasu SC, et al. Domperidone: review of pharmacology and clinical applications in gastroenterology. Am J Gastroenterol. 2007;102(9):2036-2045./[3]Champion MC, et al. Domperidone, a new dopamine antagonist. CMAJ. 1986;135(5):457-461./[4]Stoetzer C, et al. Cardiotoxic Antiemetics Metoclopramide and Domperidone Block Cardiac Voltage-Gated Na+ Channels. Anesth Analg. 2017 Jan. 124(1):52-60.
Molecular Weight: 463.95
Research Area: Neurological Disease
Target: Dopamine Receptor;Isotope-Labeled Compounds
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