Product Description: Enasidenib-d6 (AG-221-d6) is the deuterium labeled Enasidenib (HY-18690)[1]. Enasidenib is an oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes, with IC50s of 100 and 400 nM against IDH2R140Q and IDH2R172K, respectively[2].
Formula: C19H11D6F6N7O
References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
CAS Number: 2095569-76-7
Molecular Weight: 479.41
Research Area: Others
Solubility: 10 mM in DMSO
Target: Isocitrate Dehydrogenase (IDH);Isotope-Labeled Compounds