Entinostat-d4

Product Description: Entinostat-d4 is the deuterium labeled Entinostat[1]. Entinostat is an oral and selective class I HDAC inhibitor, with IC50s of 243 nM, 453 nM, and 248 nM for HDAC1, HDAC2, and HDAC3, respectively[2].

Applications: Cancer-programmed cell death

Formula: C21H16D4N4O3

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Lauffer BE, et al. Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability. J Biol Chem. 2013 Sep 13;288(37):26926-43.

Molecular Weight: 380.43

Compound Purity: 90.31

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Apoptosis;Autophagy;HDAC

• SKU: MEXHY-12163S-500UG
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-12163S-500UG
• Package Unit: 500 μg
• Quantity Unit: STK