FGFR2/3-IN-1, CAS 2640352-86-7

Product Description: FGFR2/3-IN-1 is a potent and selective FGFR2 and FGFR3 (FGFR) inhibitor with IC50s of 1 nM and 0.5 nM, respectively. FGFR2/3-IN-1 displays >40-fold selectivity over FGFR1/FGFR4 and other kinome. FGFR2/3-IN-1 also inhibits FGFR3 V555L and V555M mutants with IC50s of 2.7 nM and 6.1 nM, respectively[1].

Applications: Cancer-Kinase/protease

Formula: C23H22D3N7O3

References: [1]Artem Shvartsbart, et al. Discovery of Potent and Selective Inhibitors of Wild-Type and Gatekeeper Mutant Fibroblast Growth Factor Receptor (FGFR) 2/3. J Med Chem. 2022 Nov 24;65(22):15433-15442.

CAS Number: 2640352-86-7

Molecular Weight: 450.51

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: FGFR

• SKU: MEXHY-151903S-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-151903S-1
• Package Unit: 1 mg
• Quantity Unit: STK