Product Description: Florfenicol-13C6 (SCH-25298-13C6) is 13C labeled Florfenicol. Florfenicol ((-)-Florfenicol) is an orally active broad-spectrum antibacterial antibiotic with anti-inflammatory, pro apoptotic, and immunomodulatory functions[6][7].
Applications: COVID-19-immunoregulation
Formula: C6 13C6H14Cl2FNO4S
References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216./[2]Hu D, et al. Florfenicol-induced Mitochondrial Dysfunction Suppresses Cell Proliferation and Autophagy in Fibroblasts. Sci Rep. 2017 Oct 19;7(1):13554./[3]Arslan P, et al. In vitro effects of erythromycin and florfenicol on primary cell lines of Unio crassus and Cyprinus carpio. Environ Sci Pollut Res Int. 2021 Sep;28(35):48408-48416./[4]Al-Shahrani S, et al. Florfenicol induces early embryonic death in eggs collected from treated hens. BMC Vet Res. 2015 Aug 18;11:213. /[5]Wang X, et al. Florfenicol induced renal inflammatory response and apoptosis via cell adhesion molecules signaling pathway. Poult Sci. 2022 Nov;101(11):102152./[6]Lis M, et al. Modulation of lymphocyte subsets and humoral immune response by florfenicol administered to sheep red blood cell-immunized broiler chickens. Pol J Vet Sci. 2019 Dec;22(4):481-487. /[7]Xinxin C, et al. Florfenicol inhibits allergic airway inflammation in mice by p38 MAPK-mediated phosphorylation of GATA 3. Clin Immunol. 2011 Feb;138(2):231-8. /[8]Shuang G, et al. Immunosuppressive activity of florfenicol on the immune responses in mice. Immunol Invest. 2011;40(4):356-66.
Molecular Weight: 364.17
Research Area: Infection;Inflammation/Immunology
Target: Antibiotic;Bacterial;Isotope-Labeled Compounds
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