Glasdegib-d4

Product Description: Glasdegib-d4 (PF-04449913-d4) is deuterium labeled Glasdegib. Glasdegib (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. Glasdegib (PF-04449913) binds to human SMO (amino acids 181-787) with an IC50 of 4 nM[1][2].

Applications: Cancer-programmed cell death

Formula: C21H18D4N6O

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Sadarangani A, et al. GLI2 inhibition abrogates human leukemia stem cell dormancy. J Transl Med. 2015 Mar 21;13:98.

Molecular Weight: 378.46

Research Area: Cancer

Target: Isotope-Labeled Compounds;Smo

• SKU: MEXHY-16391S1-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-16391S1-0
• Package Unit: Get quote
• Quantity Unit: STK