Product Description: Guanfacine-13C,d5 hydrochloride is the deuterium and 13C labeled Guanfacine hydrochloride (HY-17416). Guanfacine hydrochloride is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD)[1][2][3].
Applications: Metabolism-protein/nucleotide metabolism
Formula: C8 13CH5D5Cl3N3O
References: [1]Arnsten AF, et al. Guanfacine for the treatment of cognitive disorders: a century of discoveries at Yale. Yale J Biol Med. 2012 Mar;85(1):45-58. Epub 2012 Mar 29./[2]Van Zwieten PA, et al. The pharmacology of centrally acting antihypertensive drugs. Br J Clin Pharmacol. 1983;15(Suppl 4):455S–462S./[3]Wang M, et al. Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex. Cell. 2007 Apr 20;129(2):397-410.
Molecular Weight: 288.58
Research Area: Endocrinology; Cardiovascular Disease
Solubility: 10 mM in DMSO
Target: Adrenergic Receptor;Isotope-Labeled Compounds
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