HPK1-IN-40-d2

Product Description: HPK1-IN-40 (compound 49) is a potent and selective HPK1 inhibitor with an IC50 of 0.9 nM. HPK1-IN-40 reinvigorates T-cell receptor (TCR) signaling, promoting T-cell function and cytokine production in T cells while having anti-cancer activity[1].

Applications: COVID-19-immunoregulation

Formula: C24H20D2FN7O3

References: [1] Jing Ai, et al. Design, Synthesis, and Pharmacological Evaluation of Isoindoline Analogues as New HPK1 Inhibitors. Journal of Medicinal Chemistry. 2023，Article ASAP.

Molecular Weight: 477.49

Research Area: Cancer; Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: MAP4K

• SKU: MEXHY-149773S-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-149773S-1
• Package Unit: 1 mg
• Quantity Unit: STK