Ibudilast-d7-1, CAS 1204192-90-4

Product Description: Ibudilast-d7-1 is the deuterium labeled Ibudilast[1]. Ibudilast (KC-404;AV-411;MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia[2].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C14H11D7N2O

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Mizuno T, et al. Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia. Neuropharmacology. 2004 Mar;46(3):404-11.

CAS Number: 1204192-90-4

Molecular Weight: 237.35

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: Phosphodiesterase (PDE)

• SKU: MEXHY-B0763S2-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-B0763S2-1
• Package Unit: 1 mg
• Quantity Unit: STK