MAT2A-IN-23, CAS 2925324-58-7

Product Description: MAT2A-IN-23 (compound 39) is a MAT2A inhibitor, with an IC50 of 4 nM. MAT2A-IN-23 inhibits SAM in the HCT-116 (MTAP−/−) and in the HCT-116 WT cell line with IC50s of 3 and 2 nM, respectively. MAT2A-IN-23 inhibits SDMA in the HCT-116 (MTAP−/−) and in the HCT-116 WT cell line with IC50s of 2 and >3000 nM, respectively. MAT2A-IN-23 inhibits HCT-116 (MTAP−/−) cell proliferation with with an IC50 of 47 nM[1].

Formula: C19H14D3F2N3O

References: [1]Yang S, et al. Discovery of Novel Spirocyclic MAT2A Inhibitors Demonstrating High In Vivo Efficacy in MTAP-Null Xenograft Models. J Med Chem. 2025 Feb 13;68(3):3480-3494.

CAS Number: 2925324-58-7

Molecular Weight: 344.37

Research Area: Cancer

Target: Methionine Adenosyltransferase (MAT)

• SKU: MEXHY-170906S-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-170906S-0
• Package Unit: Get quote
• Quantity Unit: STK