Mavatrep-d6

Product Description: Mavatrep-d6 (JNJ-39439335-d6) is a deuterated labeled Mavatrep (HY-16935). Mavatrep (JNJ-39439335) is an orally active, selective and potent TRPV1 antagonist with high affinity for hTRPV1 channels (Ki=6.5 nM). Mavatrep antagonizes capsaicin-induced Ca2+ influx with an IC50 value of 4.6 nM. Mavatrep can be used in some studies of neuropathic pain[1].

Formula: C25H15D6F3N2O

References: [1]William H. Parsons, et al. Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep). J. Med. Chem. 2015, 58, 9, 3859-3874.

Molecular Weight: 428.48

Research Area: Neurological Disease

Target: Isotope-Labeled Compounds;TRP Channel

• SKU: MEXHY-16935S-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-16935S-0
• Package Unit: Get quote
• Quantity Unit: STK