Odevixibat-d5

Product Description: Odevixibat-d5 is deuterated labeled Odevixibat (HY-109120). Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis[1].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C37H43D5N4O8S2

References: [1]Baghdasaryan A, et al. Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis.J Hepatol. 2016 Mar;64(3):674-81./[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

Molecular Weight: 745.96

Research Area: Metabolic Disease

Solubility: 10 mM in DMSO

Target: Apical Sodium-Dependent Bile Acid Transporter;Isotope-Labeled Compounds

• SKU: MEXHY-109120S-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-109120S-1
• Package Unit: 1 mg
• Quantity Unit: STK