Product Description: Ofloxacin-d8 (Hoe-280-d8) is the deuterium labeled Ofloxacin. Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase.
Applications: COVID-19-immunoregulation
Formula: C18H12D8FN3O4
References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216./[2]Todd PA, et al. Ofloxacin. A reappraisal of its antimicrobial activity, pharmacology and therapeutic use. Drugs. 1991 Nov;42(5):825-76./[3]Smith JT, et al. Ofloxacin, a bactericidal antibacterial. Chemotherapy. 1991;37 Suppl 1:2-13./[4]Olcay E, et al. Oral toxicity of pefloxacin, norfloxacin, ofloxacin and ciprofloxacin: comparison of biomechanical and histopathological effects on Achilles tendon in rats. J Toxicol Sci. 2011 Jun;36(3):339-45.
CAS Number: 1219170-21-4
Molecular Weight: 369.42
Compound Purity: 99.90
Research Area: Infection
Solubility: 10 mM in DMSO/DMF : ≥ 2mg/mL/DMSO : ≥ 2mg/mL
Target: Antibiotic;Bacterial;Isotope-Labeled Compounds
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