Product Description: Physcion-d3 (Parietin-d3) is the deuterium labeled Physcion (HY-N0108). Physcion acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively. Physcion exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects[1][2][3].
Applications: COVID-19-immunoregulation
Formula: C16H9D3O5
References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216./[2]Lin R, et al. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484-96./[3]Pang MJ, et al. Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma. Acta Pharmacol Sin. 2016 Dec;37(12):1623-1640.
CAS Number: 1215751-27-1
Molecular Weight: 287.28
Compound Purity: 99.82
Research Area: Cancer; Infection; Inflammation/Immunology
Solubility: DMF : 1mg/mL (ultrasonic)/DMSO : 3.33mg/mL (ultrasonic;warming;adjust pH to 9 with NaOH;heat to 60°C)/THF : 2.5mg/mL (ultrasonic;warming;heat to 60°C)
Target: Bacterial;Isotope-Labeled Compounds
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