Piezo1 agonist 1-d2, CAS 3058199-62-2

Product Description: Piezo1 agonist 1-d2 (Compound 12a) is an agonist for Piezo1 with an EC50 of 2.21 μM. Piezo1 agonist 1-d2 activates the Ca2+-related ERK signaling pathway, and thus promotes the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). Piezo1 agonist 1-d2 ameliorates disuse osteoporosis in the hindlimb-unloading (HU) rat model[1].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C16H13D2Cl2N5OS2

References: [1]Tang H, et al., Structural Modification and Pharmacological Evaluation of (Thiadiazol-2-yl)pyrazines as Novel Piezo1 Agonists for the Intervention of Disuse Osteoporosis. J Med Chem. 2024 Nov 14;67(21):19837-19851.

CAS Number: 3058199-62-2

Molecular Weight: 430.37

Research Area: Metabolic Disease

Target: ERK;Piezo Channel

• SKU: MEXHY-169332-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-169332-0
• Package Unit: Get quote
• Quantity Unit: STK