Product Description: Pipecolic acid-d9 is the deuterium labeled Pipecolic acid. Pipecolic acid is a metabolite of lysine and an important precursor for many useful microbial secondary metabolites. Pipecolic acid slows ferroptosis in diabetic retinopathy by inhibiting the YAP-GPX4 signaling pathway. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy[1][2][3].
Applications: Metabolism-protein/nucleotide metabolism
Formula: C6H2D9NO2
References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216./[2]He M, et al. Pipecolic acid in microbes: biosynthetic routes and enzymes. J Ind Microbiol Biotechnol. 2006 Jun;33(6):401-7./[3]Plecko B, et, al. Pipecolic acid as a diagnostic marker of pyridoxine-dependent epilepsy. Neuropediatrics. 2005 Jun;36(3):200-5.
CAS Number: 790612-94-1
Molecular Weight: 138.21
Compound Purity: 99.59
Research Area: Infection
Solubility: H2O : 50 mg/mL (ultrasonic;warming)
Target: Endogenous Metabolite;Ferroptosis;Glutathione Peroxidase;Isotope-Labeled Compounds;YAP
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