Product Description: Pseudouridine-18O is the 18O labeled Pseudouridine (HY-113061). Pseudouridine is an isomer of the nucleoside uridine, and the most abundant modified nucleoside in non-coding RNAs. Pseudouridine in rRNA and tRNA can fine-tune and stabilize the regional structure and help maintain their functions in mRNA decoding, ribosome assembly, processing and translation.
Applications: Metabolism-protein/nucleotide metabolism
Formula: C9H12N2O5 18O
References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Carlile TM, et al. Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells. Nature. 2014 Nov 6;515(7525):143-6./[3]M Charette, et al. Pseudouridine in RNA: what, where, how, and why. IUBMB Life. 2000 May;49(5):341-51./[4]Junhui Ge, et al. RNA pseudouridylation: new insights into an old modification. Trends Biochem Sci. 2013 Apr;38(4):210-8./[5]Anne C Rintala-Dempsey, et al. Eukaryotic stand-alone pseudouridine synthases - RNA modifying enzymes and emerging regulators of gene expression? RNA Biol. 2017 Sep 2;14(9):1185-1196.
Molecular Weight: 246.20
Research Area: Others
Solubility: 10 mM in DMSO
Target: DNA/RNA Synthesis;Endogenous Metabolite;Isotope-Labeled Compounds;Nucleoside Antimetabolite/Analog
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