Product Description: (R)-(-)-Felodipine-d5 is the deuterium labeled (R)-(-)-Felodipine. (R)-(-)-Felodipine is the S enantiomer of Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier[1][2][3].
Formula: C18H14D5Cl2NO4
References: [1]Johnson JD, et al. Calcium and calmodulin antagonists binding to calmodulin and relaxation of coronary segments. J Pharmacol Exp Ther. 1983;226(2):330-334.;Siddiqi FH, et al. Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to r/[2]Siddiqi FH, et al. Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing. Nat Commun. 2019 Apr 18;10(1):1817./[3]Siddiqi FH, et al. Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing. Nat Commun. 2019 Apr 18;10(1):1817.
CAS Number: 1217744-87-0
Molecular Weight: 389.28
Research Area: Cardiovascular Disease
Solubility: 10 mM in DMSO
Target: Autophagy;Calcium Channel;Isotope-Labeled Compounds
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