Product Description: Rhein-13C4 (Rheic Acid-13C4) is 13C labeled Rhein. Rhein is an anthraquinone compound with anti-inflammatory, antioxidant, and anti-cancer effects[1].
Applications: COVID-19-immunoregulation
Formula: C11 13C4H8O6
References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216./[2]Heo SK, et al. Rhein augments ATRA-induced differentiation of acute promyelocytic leukemia cells. Phytomedicine. 2018 Oct 1;49:66-74./[3]Zhao YL, et al. Rhein protects against acetaminophen-induced hepatic and renal toxicity. Food Chem Toxicol. 2011 Aug;49(8):1705-10. /[4]Fernand VE, et al. Rhein inhibits angiogenesis and the viability of hormone-dependent and -independent cancer cells under normoxic or hypoxic conditions in vitro. Chem Biol Interact. 2011 Jul 15;192(3):220-32./[5]Hou ML, et al. The Drug-Drug Effects of Rhein on the Pharmacokinetics and Pharmacodynamics of Clozapine in Rat Brain Extracellular Fluid by In Vivo Microdialysis. J Pharmacol Exp Ther. 2015 Oct;355(1):125-34.
CAS Number: 1189928-10-6
Molecular Weight: 288.19
Research Area: Cancer;Infection;Inflammation/Immunology
Target: Apoptosis;Autophagy;Bacterial;Isotope-Labeled Compounds;Reactive Oxygen Species
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