Product Description: Ribociclib-d6 is a deuterium labeled Ribociclib. Ribociclib is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1].
Applications: Cancer-Kinase/protease
Formula: C23H24D6N8O
References: [1]VanArsdale T, et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1;21(13):2905-10.
CAS Number: 1328934-40-2
Molecular Weight: 440.57
Compound Purity: 99.47
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: CDK