Product Description: Riboflavin-d8 (Vitamin B2-d8 ) is deuterium labeled Riboflavin. Riboflavin, an orally active and easily absorbed micronutrient, is a precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which serve as coenzymes for numerous enzymatic reactions and perform key metabolic functions by mediating the transfer of electrons in biological oxidation-reduction reaction[1].
Applications: Metabolism-protein/nucleotide metabolism
Formula: C17H12D8N4O6
References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216./[2]Thakur K, et al. Riboflavin and health: A review of recent human research. Crit Rev Food Sci Nutr. 2017 Nov 22;57(17):3650-3660./[3]de Souza AC, et al. A promising action of riboflavin as a mediator of leukaemia cell death. Apoptosis. 2006 Oct;11(10):1761-71./[4]Xin Z, et al. Riboflavin deficiency induces a significant change in proteomic profiles in HepG2 cells. Sci Rep. 2017 Apr 3;7:45861./[5]Agte VV, et al. Effect of riboflavin supplementation on zinc and iron absorption and growth performance in mice. Biol Trace Elem Res. 1998 Nov;65(2):109-15./[6]Granados-Soto V, et al. Riboflavin reduces hyperalgesia and inflammation but not tactile allodynia in the rat. Eur J Pharmacol. 2004 May 10;492(1):35-40./[7]França DS, et al. B vitamins induce an antinociceptive effect in the acetic acid and formaldehyde models of nociception in mice. Eur J Pharmacol. 2001 Jun 15;421(3):157-64.
Molecular Weight: 384.41
Research Area: Cancer;Metabolic Disease
Target: Bacterial;Endogenous Metabolite;Isotope-Labeled Compounds
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