Product Description: Rosuvastatin-d3 is a deuterium labeled Rosuvastatin. Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM[1]. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals[2].
Applications: Cancer-programmed cell death
Formula: C22H25D3FN3O6S
References: [1]Watanabe, M., et al., Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Bioorg Med Chem, 1997. 5(2): p. 437-44./[2]Carswell C.I., et al. Rosuvastatin. Drugs, 2002. 62(14): p. 2075-85; discussion 2086-7.
CAS Number: 1133429-16-9
Molecular Weight: 484.56
Research Area: Metabolic Disease; Cardiovascular Disease
Solubility: 10 mM in DMSO
Target: Autophagy;HMG-CoA Reductase (HMGCR);Isotope-Labeled Compounds;Potassium Channel
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