Product Description: Sorafenib-d4 is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.
Applications: Cancer-Kinase/protease
Formula: C21H12D4ClF3N4O3
References: [1]Wilhelm SM, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004 Oct 1;64(19):7099-109.
CAS Number: 1207560-07-3
Molecular Weight: 468.85
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: Apoptosis;Autophagy;Ferroptosis;FLT3;Raf;VEGFR