Tetrahydrocortisol-d5

Product Description: Tetrahydrocortisol-d5 is the deuterium labeled Tetrahydrocortisol. Tetrahydrocortisol is cortisol metabolite. The urinary Tetrahydrocortisol/Tetrahydrocortisone ratio decreases with increasing 11β-hydroxysteroid dehydrogenase (11β-HSD) activity[1][2].

Formula: C21H29D5O5

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. /[2]Webster SP, et al. Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™). Br J Pharmacol. 2017 Mar;174(5):396-408./[3]Turpeinen U, et al. Determination of free tetrahydrocortisol and tetrahydrocortisone ratio in urine by liquid chromatography-tandem mass spectrometry. Scand J Clin Lab Invest. 2006;66(2):147-59.

Molecular Weight: 371.52

Compound Purity: 99.19

Research Area: Metabolic Disease

Solubility: 10 mM in DMSO

Target: Endogenous Metabolite;Isotope-Labeled Compounds

• SKU: MEXHY-129630S-500UG
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-129630S-500UG
• Package Unit: 500 μg
• Quantity Unit: STK