Tivozanib-d6, CAS 1714998-87-4

Product Description: Tivozanib-d6 (AV-951-d6) is deuterium labeled Tivozanib. Tivozanib (AV-951; KRN951) is a selective, orally active inhibitor for vascular endothelial growth factor receptor (VEGFR)-1, 2 3, with IC50s of 30, 6.5 and 15 nM, respectively. Tivozanib exhibits antitumor efficacy[1][2].

Formula: C22H13D6ClN4O5

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Nakamura K, et al., KRN951, a highly potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, has antitumor activities and affects functional vascular properties. Cancer Res. 2006 Sep 15;66(18):9134-42.

CAS Number: 1714998-87-4

Molecular Weight: 460.90

Research Area: Cancer

Target: Isotope-Labeled Compounds;VEGFR

• SKU: MEXHY-10977S-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-10977S-0
• Package Unit: Get quote
• Quantity Unit: STK