Product Description: Tolbutamide-d9 is the deuterium labeled Tolbutamide. Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic agent.
Formula: C12H9D9N2O3S
References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. /[2]Wray, H.L. and A.W. Harris, Adenosine 3', 5'-monophosphate-dependent protein kinase in adipose tissue: inhibition by tolbutamide. Biochem Biophys Res Commun, 1973. 53(1): p. 291-4./[3]Sanchez-Alvarez, R., et al., Tolbutamide reduces glioma cell proliferation by increasing connexin43, which promotes the up-regulation of p21 and p27 and subsequent changes in retinoblastoma phosphorylation. Glia, 2006. 54(2): p. 125-34.
CAS Number: 1219794-57-6
Molecular Weight: 279.40
Compound Purity: 99.0
Research Area: Metabolic Disease; Cancer
Solubility: 10 mM in DMSO/DMF : ≥ 30mg/mL/DMSO : ≥ 30mg/mL/Ethanol : ≥ 30mg/mL
Target: Autophagy;Potassium Channel
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