Trandolaprilate-d6

Product Description: Trandolaprilate-d6 is the deuterium labeled Trandolaprilate[1]. Trandolaprilate is a potent angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilate partially inhibits angiotensin-I-mediated c-fos induction. Trandolaprilate is main bioactive metabolite of Trandolapril. Trandolaprilate shows high lipophilicity[2][3].

Applications: Neuroscience-Neuromodulation

Formula: C22H24D6N2O5

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Millet D, et al. Effects of angiotensins on cellular hypertrophy and c-fos expression in cultured arterial smooth muscle cells. Eur J Biochem. 1992 Jun 1;206(2):367-72./[3]Al-Hawash LA, et al. Stability-indicating HPLC determination of trandolapril in bulk drug and pharmaceutical dosage forms. Int J Anal Chem. 20152015:820517.

Molecular Weight: 408.52

Research Area: Cardiovascular Disease

Solubility: 10 mM in DMSO

Target: Angiotensin-converting Enzyme (ACE);Endogenous Metabolite

• SKU: MEXHY-A0116S1-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-A0116S1-1
• Package Unit: 1 mg
• Quantity Unit: STK