Product Description: Tropicamide (Ro 1-7683) is a selective M4 muscarinic acetylcholine receptor antagonist. When used as an eye drop, Tropicamide causes short-term mydriasis (pupil dilation) and cycloplegia. Tropicamide can be used in the research of neurological diseases, such as epilepsy[1][2][3][4].
Applications: Neuroscience-Neuromodulation
Formula: C17H20N2O2
References: [1]Lazareno, S., N.J. Buckley, and F.F. Roberts, Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cells. Mol Pharmacol, 1990. 38(6): p. 805-15./[2]Hernandez, M., et al., Different muscarinic receptor subtypes mediating the phasic activity and basal tone of pig isolated intravesical ureter. Br J Pharmacol, 1993. 110(4): p. 1413-20./[3]Veeraragavan S, et al. The modulation of fragile X behaviors by the muscarinic M4 antagonist, tropicamide. Behav Neurosci. 2011 Oct;125(5):783-90./[4]Betz AJ, et al. The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 receptors. Psychopharmacology (Berl). 2007 Oct;194(3):347-59.
CAS Number: 1508-75-4
Molecular Weight: 284.35
Compound Purity: 99.22
Research Area: Neurological Disease
Solubility: DMSO : 25 mg/mL (ultrasonic)
Target: mAChR
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