VcMMAE-d8

Product Description: VcMMAE-d8 is an isotope of VcMMAE (HY-15575). VcMMAE-d8 is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc)[1].

Applications: Cancer-programmed cell death

Formula: C68H97D8N11O15

References: [1]Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16(3), 888-897.

Molecular Weight: 1324.68

Compound Purity: 97.56

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Drug-Linker Conjugates for ADC;Microtubule/Tubulin

• SKU: MEXHY-15575S-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-15575S-1
• Package Unit: 1 mg
• Quantity Unit: STK