ZJY-54

Product Description: ZJY-54 is an orally active dual-target inhibitor of EGFR/LSD1, with IC50 values of 3.8 nM and 0.6 μM, respectively. ZJY-54 can inhibit the proliferation of non-small cell lung cancer cells, induce the accumulation of H3K4me2 and H3K9me2, and inhibit the phosphorylation of the EGFR signaling pathway. ZJY-54 has anti-tumor activity[1].

Formula: C29H30D3N7O2

References: [1]Zhang J, et al. Structure-Based Design of New LSD1/EGFRL858R/T790M Dual Inhibitors for Treating EGFR Mutant NSCLC Cancers. J Med Chem. 2025 Mar 13;68(5):5954-5972.

Molecular Weight: 514.64

Research Area: Cancer

Target: EGFR;Histone Demethylase

• SKU: MEXHY-168968S-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-168968S-0
• Package Unit: Get quote
• Quantity Unit: STK