BMS 986260, CAS 2001559-19-7

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 6-[4-(3-chloro-4-fluorophenyl)-1-(2-hydroxyethyl)-1H-imidazol-5-yl]-imidazo[1,2-b]pyridazine-3-carbonitrile

Purity: ≥98%

Formula Markup: C18H12ClFN6O

Formula Weight: 382.778823

CAS Number: 2001559-19-7

Notes: An ALK5 inhibitor (IC50 = 0.0015 µM); selective for ALK over TGF-βRII (IC50 = > 15 µM) and a panel of 213 additional kinases at 1 µM; inhibits TGF-β-induced increases in the nuclear translocation of phosphorylated SMAD2/3 in Mv 1 Lu cells (IC50 = 0.35 µM); decreases tumor growth in an MC-38 murine colon carcinoma model of tumor rechallenge at 3.75 mg/kg per day in combination with an antibody against PD-1; induces hyperproliferation of chondrocytes in the femoral epiphysis, thickening of the cardiac atrioventricular valve, and inflammation in the aortic vasculature in rats at 10 mg/kg per day

• SKU: CAY42042-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42042-50
• Package Unit: 50 mg
• Quantity Unit: STK